On a typical 8-bit bus running at 10 MHz, that leaves about 75 ns of margin after address setup — comfortable for most legacy 5V controllers, but tight if you're pushing a 20 MHz clock.
5V-only supply — not a 3.3V drop-in
Supply range is 4.5V to 5.5V — this is a pure 5V part.
Active production — no end-of-life scramble
Renesas lists the 6116LA25SOG8 as Active and ROHS3 compliant. No PCN or last-time-buy window to track — you can commit this to a production BOM without worrying about a sudden obsolescence notice.
