RS-232 link in a 16-TSSOP footprint
The MAX3221ECUE+ is a single RS-232 transceiver handling one full-duplex serial link with one driver and one receiver in a 16-TSSOP package. Data rate is 250 kbps.

Analog Devices MAX3221ECUE+, RS-232 Transceiver, Full Duplex, 1/1 Driver/Receiver, 250 kbps Data Rate, 3V to 5.5V Supply, 16-TSSOP Package, 0°C to 70°C.
| Parameter | Value |
|---|---|
| Type | Transceiver |
| Mounting | Surface Mount |
| Voltage | 3V ~ 5.5V |
| Protocol | RS232 |
| Operating temperature | 0°C ~ 70°C |
| Duplex | Full |
| Package | Tube |
| Data rate | 250kbps |
| Case | 16-TSSOP (0.173\", 4.40mm Width) |
| Receiver hysteresis | 500 mV |
| Number of drivers (Receivers) | 1/1 |
The MAX3221ECUE+ is a single RS-232 transceiver handling one full-duplex serial link with one driver and one receiver in a 16-TSSOP package. Data rate is 250 kbps.
The MAX3221EEUE+ is the industrial-temperature version rated -40°C to +85°C, while the MAX3221ECUE+ is commercial-grade 0°C to 70°C. Both share the same 16-TSSOP package, pinout, supply range, and 250 kbps data rate. Choose the EEUE+ for outdoor or factory-floor environments; the ECUE+ for indoor, climate-controlled equipment.
Yes, the supply range of 3V to 5.5V covers 3.3V operation directly. You can power it from a 3.3V rail and interface with a 3.3V UART without extra level shifting.
The closest pin-compatible equivalent is the MAX3221EEUE+, which differs only in temperature grade. For a different package or channel count, look at the MAX3221 family — but for a drop-in replacement in the 16-TSSOP footprint, the EEUE+ is the direct alternate.