What the ratings mean for your BOM
The 150 mW per channel into 16 Ω is the headline figure — it tells you the amplifier can swing enough voltage and current to drive low-impedance headphones to reasonable SPL. The 2.5 V minimum supply means this part works from a nearly depleted Li-ion cell without a boost converter. Built-in depop circuitry suppresses the turn-on/turn-off pop that would otherwise require external muting FETs or series capacitors with bleed resistors. Short-circuit and thermal protection mean you can skip a dedicated protection IC — the amplifier handles a momentary output short without damage.
The TPA6111A2DGN is listed as Active on the manufacturer's lifecycle status, with ROHS3 compliance.