NRND — not a new-design part, but still a current BOM line
For a BOM that already uses this MCU, the NRND flag is a watch item — not an immediate stop-ship, but a signal to evaluate a migration path during the next board revision.
If your board already carries a 3.3 V bus, you will need a separate LDO or buck converter to generate this 2.5 V nominal supply. The 50 MHz core speed is achievable across the full voltage range, but the flash requires zero wait states at this clock — no extra latency penalty for the narrow rail.
108-ball BGA — assembly and rework considerations
The substrate requires a controlled reflow profile per the board-level reliability guidelines. X-ray inspection after assembly is recommended to verify solder-joint integrity.