Clamping and breakdown — the two numbers that decide the fit
The 5KP160A_R2_00001: Reverse standoff is 160 V typ — the voltage the TVS sees in normal operation without conduction. Breakdown threshold sits at a minimum of 178 V, which means the device stays off below that point and turns on hard once the transient pushes the line above it. At the 19 A peak pulse current, the clamping voltage clamps at a maximum of 259 V. That 259 V ceiling is what the protected load sees — if your downstream rail is rated at 200 V absolute maximum, this part is cutting it close and you move up to the next standoff voltage in the series.
Junction temperature and through-hole package
The P600 axial package mounts through-hole into a PCB; the lead length and pad design affect the thermal path from junction to ambient.
The base product number 5KP160 anchors the part to the series, which carries multiple standoff voltage options; if your system needs a different stand-off, the series cross-reference is the migration path.