The 26.5 mOhm maximum on-resistance at 22 A with 10 V gate drive sets the conduction loss baseline for a 48 V or 72 V bus design. Total gate charge of 63 nC at 10 V means a standard gate-driver IC can switch it in the tens-of-kilohertz range without excessive drive current.
The gate threshold voltage maximum of 4 V at 250 µA means a 5 V logic-level gate drive will turn it on, but the Rds(on) will be significantly higher than the 10 V figure — the drive voltage for minimum Rds(on) is 10 V. For a 12 V gate drive rail the 63 nC gate charge is manageable with a standard totem-pole driver; at higher switching frequencies the input capacitance of 1770 pF at 25 V drain-source becomes the dominant switching loss term.